Refuse leachate exposure causes changes of thyroid hormone level and related gene expression in female goldfish (Carassius auratus)
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- 作者：Yufeng Gong ; Hua Tian ; Xiaona Zhang ; Yifei Dong ; Wei Wang ; Shaoguo Ru ; rusg@ouc.edu.cn
- 关键词：TH ; thyroid hormone ; TSH ; thyroid-stimulating hormone ; T4 ; 3 ; 3ʹ ; 5 ; 5ʹ-l-thyroxine ; T3 ; 3 ; 3ʹ ; 5-triiodo-l-thyronine ; ID1 ; type I iodothyronine deiodinase ; ID2 ; type II iodothyronine deiodinase ; ID3 ; type III iodothyronine deiodinase ; TRs ; thyroid receptors ; TDCs ; thyroid-disrupting chemicals ; MBR ; membrane bioreactor ; DTRO ; disc-tube reverse osmosis ; MS-222 ; ethyl 3-aminobenzoate methanesulfonic acid ; RIA ; radioimmunoassay ; PCR ; polymerase chain reaction ; ANOVA ; analysis of variance ; rT3 ; 3 ; 3ʹ ; 5ʹ-t
- 刊名：Environmental Toxicology and Pharmacology
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：48
- 期：Complete
- 页码：46-52
- 全文大小：1738 K
- 卷排序：48
文摘
The effects of leachate on thyroid system of female fish remain unknown. Leachate exposure induced elevated plasma T3 and TSH levels. The expression profiles of HPT axis-responsive genes were altered. After treatment, the leachate still possesses potential thyroid disrupting activity. The thyroid system in female seems to be more sensitive than that of the male.