Acute exposure to synthetic pyrethroids causes bioconcentration and disruption of the hypothalamus-pituitary-thyroid axis in zebrafish embryos
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- 作者：Wenqing Tua ; b ; Chao Xub ; chaoxu@zjut.edu.cn" class="auth_mail" title="E-mail the corresponding author ; Bin Lub ; Chunmian Linb ; Yongming Wua ; Weiping Liuc
- 关键词：SPs ; synthetic pyrethroids ; BF ; bifenthrin ; λ-CH ; λ-cyhalothrin ; CRH ; corticotropin-releasing hormone ; TSH ; thyroid stimulating hormone ; TTR ; transthyretin ; UGT1ab ; uridine diphosphate glucuronosyltransferase ; TPO ; thyroid peroxidase ; TG ; thyroglobulin ; NKX2.1 (also known as TTF1) ; thyroid transcription factor-1 ; Pax8 ; paired box gen 8 ; Dio ; deiodinase ; TR ; thyroid hormone receptors ; HPT axis ; hypothalamic&ndash ; pituitary&ndash ; thyroid axis ; TH ; thyroid hormones
- 刊名：Science of the Total Environment
- 出版年：2016
- 出版时间：15 January 2016
- 年：2016
- 卷：542
- 期：part_PA
- 页码：876-885
- 全文大小：1355 K
文摘
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Following respective exposure of embryos to BF and λ-CH, thyroid endocrine disruption was investigated in zebrafish embryos.
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Thyroid hormones (T3 and T4 levels) were significantly altered after being exposed to BF and λ-CH.
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Gene transcription modulation in the HPT axis was examined.
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BF and λ-CH bioconcentration in zebrafish larvae were evident.
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BF binds to thyroid hormone receptor (TRα) protein more potently than λ-CH.