New insights on pyrimidine signalling within the arterial vasculature ‿Different roles for P2Y2 and P2Y6 receptors in large and small coronary arteries of the mouse
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- 作者：Kristian Agmund Haanesa ; kristian.agmund.haanes@regionh.dk" class="auth_mail" title="E-mail the corresponding author ; Stine Spraya ; Susanne Sybergb ; Niklas Rye Jø ; rgensenb ; e ; Bernard Robayec ; Jean-Marie Boeynaemsd ; Lars Edvinssona
- 关键词：Coronary circulation ; Knock-out mice ; Purinergic receptors ; P2Y2 ; P2Y6
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：93
- 期：Complete
- 页码：1-11
- 全文大小：1881 K
文摘
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Isolated P2Y2 and P2Y6 arteries from KO mice were analysed by myography.
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Large arteries: P2Y6 causes contraction for both UTP and UDP; P2Y2 causes relaxation.
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Smaller arteries: P2Y2 causes contraction and P2Y6 relaxation together with P2Y2.
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The receptor functionality appeared similar in systemic blood pressure measurements.
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P2Y receptor functionality changes along the coronary arterial vasculature.