Evaluation of four biodegradable, injectable bone cements in an experimental drill hole model in sheep

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• 作者：Brigitte von Rechenberg ; Oliver R. G¨¦not ; Katja Nuss ; Larry Galuppo ; Mark Fulmer ; Evan Jacobson ; Peter Kronen ; Kati Zlinszky ; J?rg A. Auer
• 关键词：Calcium phosphate cements ; Bone substitute ; Synthetic cements ; Injectable cements ; Bone cements
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2013
• 出版时间：September, 2013
• 年：2013
• 卷：85
• 期：1
• 页码：130-138
• 全文大小：2727 K

文摘

Four cement applications were tested in this investigation. Two dicalcium phosphate dihydrate (DCPD-brushite) hydraulic cements, an apatite hydraulic fiber loaded cement, and a calcium sulfate cement (Plaster of Paris) were implanted in epiphyseal and metaphyseal cylindrical bone defects in sheep. The in vivo study was performed to assess the biocompatibility and bone remodeling of four cement formulations. After time periods of 2, 4, and 6 months, the cement samples were clinically and histologically evaluated. Histomorphometrically, the amount of new bone formation, fibrous tissue, and bone marrow and the area of remaining cement were measured. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. Cements differed mainly in their resorption time. Calcium sulfate was already completely resorbed at 2 months and showed a variable amount of new bone formation and/or fibrous tissue in the original drill hole over all time periods. The two DCPD cements in contrast were degraded to a large amount at 6 months, whereas the apatite was almost unchanged over all time periods.