Independent Risk Factors for Massive Ascites After Living Donor Liver Transplantation in Adults

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• 作者：C. Li ; Q. Lu ; J. Luo ; Z. Zhang ; ^{zhangzhongweihxyy@163.com" class="auth_mail}
• 刊名：Transplantation Proceedings
• 出版年：April 2014
• 年：2014
• 卷：46
• 期：3
• 页码：883-887
• 全文大小：226 K

文摘

This study sought to define the perioperative recipient and donor factors that contribute to the occurrence of massive ascites after living donor liver transplantation (LDLT) in adults.

Methods

A retrospective review of medical records and computerized databases was performed, and 105 adult patients who underwent LDLT from 2005 to 2011 in the West China Hospital, Sichuan University, were included. Patients were divided into group 1 (n = 27, massive ascites defined as >7000 mL of ascitic fluid produced during the first 7 days after LDLT) or group 2 (n = 78, no massive ascites). Perioperative recipient and donor factors were assessed using a univariate analysis followed by 2 logistic regression analyses.

Results

The recipients' median age was 44 years (range, 27 to 69 years), and the male-to-female ratio was 92:13. Massive ascites developed in 27 patients (25.7%). The average amount of ascites in group 1 and group 2 patients within the first 7 postoperative days was 11,285 mL and 3311 mL, respectively. The univariate analysis showed that recipient's age, primary liver disease, preoperative MELD score, Child-Pugh score, operating time, postoperative sequential organ failure assessment (SOFA) score, postoperative total bilirubin, right hepatic vein graft diameter, and hepatic portal vein graft diameter were significantly different between the 2 groups (P < .05). The 2 logistic regressions showed that the Child-Pugh score, operating time, and right hepatic vein graft diameter were independent risk factors for massive ascites after LDLT.

Conclusion

It is important to improve the perioperative liver function and portal hypertension and to shorten operating time to reduce massive ascites after LDLT.