Recoding structural glycoprotein E2 in classical swine fever virus (CSFV) produces complete virus attenuation in swine and protects infected animals against disease
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- 作者：Lauro Velazquez-Salinasa ; lauro.velazquez@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Guillermo R. Risattib ; guillermo.risatti@uconn.edu" class="auth_mail" title="E-mail the corresponding author ; Lauren G. Holinkaa ; lauren.holinka@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Vivian O&rsquo ; Donnella ; b ; vivian.odonnell@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Jolene Carlsona ; d ; jolene.carlson@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Marialexia Alfanoa ; marialexia.alfano@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Luis. L. Rodrigueza ; luis.rodriguez@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Consuelo Carrilloc ; consuelo.carrillo@aphis.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Douglas P. Gladuea ; douglas.gladue@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author ; Manuel V. Borcaa ; manuel.borca@ars.usda.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：Codon usage ; Codon de-optimization ; Protection ; Vaccine development ; Classical swine fever virus
- 刊名：Virology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：494
- 期：Complete
- 页码：178-189
- 全文大小：2474 K
文摘
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Recoding classical swine fever virus E2 changes virus virulence.
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De-optimization of Codon usage causes decrease in CSFV virus growth.
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CSFV containing a de-optimized E2 sequence can protect against virulent CSFV.