The recognition of tadalafil by β-CD and SCX6 was compared.
SCX6@RGO exhibited excellent sensing performance and supramolecular recognition capability.
A sensitive electrochemical sensing platform was developed based on the SCX6@RGO.
The β-CD/tadalafil and SCX6/tadalafil complexes were studied by molecular docking.
The binding mode between β-CD/SCX6 and tadalafil was clarified.