Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice
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- 作者：Rui-san Zhanga ; b ; Zhen Hea ; Wei-dong Jina ; Rui Wanga ; wangrui@lzu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; CB1 ; cannabinoid 1 ; CB2 ; cannabinoid 2 ; BLA ; basolateral complex of the amygdala ; CNS ; central nervous system ; Hp ; hemopressin ; RVD ; (m)RVD-hemopressin(α) ; VD ; (m)VD-hemopressin(α) ; NOR ; novel object recognition ; OLR ; object location recognition ; i.c.v. ; intracerebroventricular ; Aβ1&ndash ; 42 ; amyloid-β (1&ndash ; 42) ; TET ; total exploration time ; DI ; discrimination index ; Acsf ; artificial cerebrospinal fluid ; DMSO ; dimethyl sulfoxide ; LTP ; long term synaptic potentia
- 刊名：Neurobiology of Learning and Memory
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：134
- 期：part_PB
- 页码：264-274
- 全文大小：3995 K
文摘
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I.c.v. infusion of RVD or VD impairs memory of normal mice.
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In Aβ-treated mice, i.c.v. infusion of RVD or VD improves memory impaired by Aβ.
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The above effect of RVD and VD could be inhibited by Hp or AM251.
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I.c.v. infusion of Hp improves memory of normal mice.
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The above effect of Hp could be prevented by RVD, VD or WIN55, 212-2.