Tissue engineering strategies for promoting vascularized bone regeneration
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- 作者：Sarah Almubaraka ; c ; Hubert Nethercotta ; c ; Marie Freeberga ; c ; Caroline Beaudona ; c ; Amit Jhab ; Wesley Jacksonb ; Ralph Marcucioa ; Theodore Miclaua ; Kevin Healyb ; Chelsea Bahneya ; b ; Chelsea.Bahney@UCSF.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：MSCs ; mesenchymal stem cells ; VEGF ; vascular endothelial growth factor ; PDGF ; platelet derived growth factor ; TGF-β1 & TGF-β2 ; transforming growth factor beta 1 and 2 ; IGF ; insulin-like growth factor ; FGF-2 ; fibroblast growth factor-2 ; rhPDGF-BB ; recombinant human platelet derived growth factor-BB ; PlGF ; placental growth factor ; Shh ; sonic hedgehog ; Ang ; angiopoietins ; Tie ; tyrosine kinase receptors ; HA ; hyaluronic acid ; EPCs ; endothelial progenitor cells ; OECs ; outgrowth endothelial cells ; eEPC
- 刊名：Bone
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：83
- 期：Complete
- 页码：197-209
- 全文大小：585 K
文摘
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Angiogenic growth factors play a very important role in directing neovascularization.
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Delivery methods allowing sustained release can overcome hurdles preventing the translation of growth factors to the clinic.
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Further research is needed to determine the best source of therapeutic stem cells and the benefits of stem cell co-culture.
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Cartilage grafts have the potential to promote vascularized bone regeneration through the endochondral ossification pathway.