Antibody profiles to wheat germ cell-free system synthesized Plasmodium falciparum proteins correlate with protection from symptomatic malaria in Uganda

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• 作者：Bernard N. Kanoi^a ; Eizo Takashima^a ; ^{takashima.eizo.mz@ehime-u.ac.jp} ; Masayuki Morita^a ; Michael T. White^b ; ^c ; Nirianne M.Q. Palacpac^d ; Edward H. Ntege^a ; Betty Balikagala^a ; Adoke Yeka^e ; Thomas G. Egwang^f ; Toshihiro Horii^d ; Takafumi Tsuboi^a ; ^{tsuboi.takafumi.mb@ehime-u.ac.jp}
• 关键词：Malaria ; Naturally acquired immunity ; Vaccine ; Uganda
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：873-881
• 全文大小：1018 K
• 卷排序：35

文摘

WGCFS generated P. falciparum recombinant proteins are highly immunoreactive to human sera. P. falciparum-exposed individuals raise antibodies to hundreds of parasite proteins. Fifty-three known and novel antigens are plausible targets of protective immunity. Secreted apical merozoite and sporozoite antigens are potential malaria vaccine candidates. WGCFS and AlphaScreen system are invaluable tools for malaria vaccine candidate discovery.