Tuberculosis-immune reconstitution inflammatory syndrome

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• 作者：Massimiliano Lanzafame^a ; Sandro Vento^b ; ^{ventosandro@yahoo.it" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Tuberculosis ; IRIS ; Immune reconstitution ; HIV ; Antiretrovirals
• 刊名：Journal of Clinical Tuberculosis and Other Mycobacterial Diseases
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：3
• 期：Complete
• 页码：6-9
• 全文大小：369 K

文摘

Tuberculosis-immune reconstitution inflammatory syndrome is an excessive immune response against Mycobacterium tuberculosis that may occur in either HIV-infected or uninfected patients, during or after completion of anti-TB therapy. In HIV-infected patients it occurs after initiation of antiretroviral therapy independently from an effective suppression of HIV viremia. There are two forms of IRIS: paradoxical or unmasking. Paradoxical IRIS is characterized by recurrent, new, or worsening symptoms of a treated case. Unmasking IRIS is an antiretroviral-associated inflammatory manifestation of a subclinical infection with a hastened presentation. The pathogenesis is incompletely understood and the epidemiology partially described. No specific tests can establish or rule out the diagnosis. Treatment is based on the use of anti-tuberculosis drugs sometime with adjunctive corticosteroids. Mortality is generally low.