Molluscum contagiosum-associated immune reconstitution inflammatory syndrome in human immunodeficiency virus infection

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• 作者：Hsing-San Yang¹ ; Chia-Wen Li² ; Fu-Nien Hsieh¹ ; Cheng-Han Liu¹ ; Julia Yu-Yun Lee¹ ; Chao-Chun Yang¹ ; ³ ; ^{yangcc@mail.ncku.edu.tw" class="auth_mail" title="E-mail the corresponding author}
• 关键词：human immunodeficiency virus ; immune reconstitution inflammatory syndrome ; molluscum contagiosum
• 刊名：Dermatologica Sinica
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：34
• 期：4
• 页码：196-199
• 全文大小：872 K

文摘

Immune reconstitution inflammatory syndrome (IRIS) is an excessive immune reaction to a pre-existing infection following the initiation of highly active antiretroviral therapy (HAART) in human immunodeficiency virus (HIV)-infected patients. Molluscum contagiosum-associated IRIS is rare. We report a new case and review the five other reported cases. Our patient, a 40-year-old Taiwanese male with HIV infection, presented with inflamed papules and pustules over the neck and arms occurring 1 month into HAART with recovering of CD4 cell counts. Histopathology showed molluscum contagiosum with a dense diffuse mixed inflammatory infiltrate with abundant eosinophils. The skin lesions resolved spontaneously within 3 months under continuous HAART.