Inward-rectifying K+ (Kir2) leak conductance dampens the excitability of lamina I projection neurons in the neonatal rat
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- 作者：Neil C. Ford ; Mark L. Baccei ; mark.baccei@uc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kir ; classical inward-rectifying potassium channel ; PAG ; periaqueductal gray ; PB ; parabrachial nucleus ; SDH ; superficial dorsal horn
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：17 December 2016
- 年：2016
- 卷：339
- 期：Complete
- 页码：502-510
- 全文大小：762 K
文摘
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Neonatal rat spino-PB and spino-PAG neurons express similar leak conductance through inward-rectifying K+ (Kir) channels.
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Block of Kir2 channels significantly enhances the intrinsic membrane excitability of both spino-PB and spino-PAG neurons.
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Kir2 channels may thus constitutively diminish nociceptive signal transmission from the neonatal spinal cord to the brain.