Aberrant expression of the pore-forming KATP channel subunit Kir6.2 in hippocampal reactive astrocytes in the 3xTg-AD mouse model and human Alzheimer’s disease
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- 作者：Chelsea M. Griffitha ; c ; &dagger ; ; Mi-Xin Xied ; &dagger ; ; Wen-Ying Qiue ; Andrew A. Sharpa ; b ; c ; Chao Mae ; Aihua Pand ; Xiao-Xin Yand ; f ; Peter R. Patryloa ; b ; c ; ppatrylo@siumed.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AD ; Alzheimer&rsquo ; s disease ; ALV ; alveus ; Aβ ; beta amyloid ; CNS ; central nervous system ; DAB ; diaminobenzidine ; GAPDH ; glyceraldehyde-3-phosphate ; GFAP ; glial fibrillary protein ; GS ; glutamine synthetase ; HH3 ; phosphorylated histone H3 ; IHC ; immunohistochemistry ; IR ; immunoreactivity ; Kir ; inwardly rectifying potassium channel ; SO ; stratum oriens ; SP ; stratum pyramidale ; SR ; stratum radiatum ; SUR ; sulfonylurea
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：12 November 2016
- 年：2016
- 卷：336
- 期：Complete
- 页码：81-101
- 全文大小：6981 K
文摘
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Alzheimer’s pathology is characterized by plaques, tangles and neuroinflammation.
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Aged 3xTg-AD mice recapitulate these AD characteristics.
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Aged 3xTg-AD mice and human AD tissue exhibit reactive astrocytes in hippocampal gray and white matter.
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3xTg-AD hippocampi exhibit increased plasma membrane Kir6.2, but not Kir6.1.
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Increased Kir6.2 localizes to reactive astrocytes in 3xTg mice and human AD tissue.