Description and Prevalence of Spondyloarthritis in Patients with Anterior Uveitis: The SENTINEL Interdisciplinary Collaborative Project

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• 作者：Xavier Juanola ; MD ; PhD¹ ; Estí ; baliz Loza Santamarí ; a ; MD² ; ^{estibaliz.loza@inmusc.eu" class="auth_mail" title="E-mail the corresponding author} ; Miguel Cordero-Coma ; MD ; PhD³ ; ⁴ ; for the SENTINEL Working Group^&lowast ;
• 关键词：AS ; ankylosing spondylitis ; ASAS ; Assessment of SpondyloArthritis International Society ; AU ; anterior uveitis ; HLA ; human leukocyte antigen ; IBD ; inflammatory bowel disease ; SpA ; spondyloarthritis
• 刊名：Ophthalmology
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：123
• 期：8
• 页码：1632-1636
• 全文大小：206 K

文摘

To describe and analyze the prevalence of spondyloarthritis (SpA) in patients with anterior uveitis (AU).

Design

Multicentric, observational, prospective study.

Participants

Consecutive patients with AU who were human leukocyte antigen (HLA)-B27 positive or HLA-B27 negative with more than 1 episode of AU separated by at least 3 months were selected. Patients with a previous diagnosis of SpA were excluded.

Methods

Included patients were evaluated by an ophthalmologist and a rheumatologist following a predefined visit schedule.

Main Outcome Measures

Sociodemographic and clinical variables including the diagnosis of SpA according to Assessment of SpondyloArthritis International Society (ASAS) criteria and an exhaustive ophthalmological examination (best-corrected visual acuity, intraocular pressure, biomicroscopic examination of the anterior and posterior segment of the eye, cataract evaluation, optical coherence tomography evaluating both the 1-mm central retina thickness and the optic nerve head and retinal nerve fiber layer, and visual field in a dark room with 1 eye patched) were collected. Baseline descriptive, bivariate, and concordance analyses were performed.

Results

We included 798 patients, mostly men (59%) with a mean age of 45 years; 60% were AU HLA-B27 positive, and 40% had recurrent negative AU HLA-B27. A total of 50.2% and 17.5% of patients presented axial and peripheral SpA according to ASAS criteria, respectively. Patients with AU who were HLA-B27 positive were more frequently diagnosed with axial (69.8% vs. 27.3%, P < 0.0001) and peripheral SpA (21.9% vs. 11.1%, P < 0.0001) than patients with recurrent negative AU HLA-B27. In general, we did not detect important differences between groups in the ophthalmologic variables.

Conclusions

A large percentage of patients with clinically significant AU have an undiagnosed SpA. This percentage is even higher if the HLA-B27 haplotype is positive.