Do incident and recurrent venous thromboembolism risks truly differ between heterozygous and homozygous Factor V Leiden carriers? A retrospective cohort study
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- 作者：J. Perez Boteroa ; PerezBotero.Juliana@mayo.edu" class="auth_mail" title="E-mail the corresponding author ; W.D. Ormsbya ; A.A. Ashrania ; R.D. McBane IIb ; W.E. Wysokinskib ; M.M. Patnaika ; B.R. Lewisc ; D.E. Grillc ; R.K. Pruthia ; J.A. Heita ; b ; d
- 关键词：APC ; Activated protein C ; FVa ; Factor FVa ; PCR ; Polymerase chain reaction ; PE ; Pulmonary embolism ; VTE ; Venous thromboembolism
- 刊名：European Journal of Internal Medicine
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：30
- 期：Complete
- 页码：77-81
- 全文大小：325 K
文摘
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Homozygotes studied had higher VTE prevalence and modestly lower VTE-free survival.
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VTE penetrance and phenotype severity, however, did not differ between both genotypes.
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Our findings suggest VTE management should not differ by Factor V Leiden genotype.