A concise approach for central core of trigolutes: Total synthesis of trigolute B and 3-epi-trigolute B and analogues

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• 作者：B. Narendraprasad Reddy ; C.V. Ramana ; ^{vr.chepuri@ncl.res.in}
• 关键词：Trigolute B ; Tsuji-Trost allyation ; 3-epi-trigolute B ; Iridium ; Palladium ; Dihydroxylation/ lactonization
• 刊名：Tetrahedron
• 出版年：2017
• 出版时间：16 February 2017
• 年：2017
• 卷：73
• 期：7
• 页码：888-899
• 全文大小：1040 K
• 卷排序：73

文摘

A concise approach comprising a combination of the Pd- or Ir-catalyzed Tsuji-Trost allylation and olefin dihydroxylation/acid catalyzed lactonization has been developed to construct the central spirolactone core of trigolutes with the requisite functional groups. A large number of analogues of trigolute B have been synthesized. Furthermore, the synthesis of both (±)-trigolute B and (±)-3-epi-trigolute B has been accomplished in 4–5 steps from easily accessible building blocks.