Synthesis and molecular structure of spirocyclic 2-oxindole derivatives of 2-amino-4H-pyran condensed with the pyrazolic nucleus

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• 作者：Ruslan Gr. Redkin ; Leonid A. Shemchuk ; Valentine P. Chernykh ; Oleg V. Shishkin ; Svetlana V. Shishkina
• 关键词：3-Spiro-2-oxindoles ; Pyrano[2 ; 3-c]pyrazol ; Methylene active nitriles ; Michael reaction ; X-ray diffraction analysis
• 刊名：Tetrahedron
• 出版年：2007
• 出版时间：12 November 2007
• 年：2007
• 卷：63
• 期：46
• 页码：11444-11450
• 全文大小：280 K

文摘

4,3′-Spiro[(6-amino-5-R-3-methyl-2H,4H-pyrano[2,3-c]pyrazolo)-2′-oxindoles] were synthesized based on the three-component condensation of isatins with 3-methyl-pyrazolone-5 and respective methylene active nitriles in the presence of basic catalysts. The molecular structure of the resulting compounds was proved unambiguously by X-ray diffraction.