Reduction of cytotoxicity of natural rubber latex film by coating with PMMA-chitosan nanoparticles

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• 作者：Nuttakun Kanjanathaworn^a ; Duangporn Polpanich^b ; Kulachart Jangpatarapongsa^c ; Pramuan Tangboriboonrat^a ; ^{pramuan.tan@mahidol.ac.th}
• 关键词：Chitosan ; Latex ; Nanoparticles ; Rubber ; Surface modification
• 刊名：Carbohydrate Polymers
• 出版年：2013
• 出版时间：14 August, 2013
• 年：2013
• 卷：97
• 期：1
• 页码：52-58
• 全文大小：1886 K

文摘

Poly(methyl methacrylate) (PMMA) latex stabilized by chitosan (CS) oligomer was synthesized via the miniemulsion polymerization. By using 1 % CS solution (in 0.1 M acetic acid), the spherical PMMA-CS particles with an average size of 380 nm were obtained. The positive zeta potentials at pH 2-7 confirmed the presence of CS as the outermost layer of the latex particles. Therefore, these particles directly interacted with the indigenous non-rubbers at the surface of sulphur prevulcanized natural rubber (SPNR) film. The deposition of PMMA-CS particles caused an increase in surface roughness of the coated SPNR film as a function of latex concentration and immersion time. The simple coating of the rubber substrate with PMMA-CS particles effectively reduced the in vitro cytotoxicity on L-929 cells. This study would be, therefore, helpful for development of latex gloves designed for hypersensitive users.