Plasticity in the copper-thioether bond: Manifestation in blue Cu proteins and in synthetic analogs

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• 作者：Jan Reedijk
• 关键词：Copper ; Thioether ; Biomimetic ; Plasticity ; Zinc
• 刊名：Journal of Inorganic Biochemistry
• 出版年：2012
• 出版时间：October, 2012
• 年：2012
• 卷：115
• 期：Complete
• 页码：182-185
• 全文大小：373 K

文摘

The binding of thioethers to transition metals in biological and biomimetic systems is reviewed with a focus on copper. Literature data show that copper(I) ions have a stronger tendency to bind thioethers, e.g. methionine-like ligands, than the isoelectronic Zn(II) ions. The plasticity in the Cu(II) coordination sphere, and the diffuseness of the lone pair electrons of a thioether sulfur, allow Cu(II)-S(thioether) bond distances to vary from 2.4 to 3.2 ?, as shown by an in-depth analysis of protein structures (Protein Structure Database, PDB) and molecular structures of copper coordination compounds (Cambridge Structural Database, CSD).