- 作者：Sanne M. van der Kooij ; Wouter J.K. Hehenkamp ; Nicole A. Volkers ; Erwin Birnie ; Willem M. Ankum ; Jim A. Reekers
- 关键词：fibroid tumor ; hysterectomy ; menorrhagia ; uterine artery embolization
- 刊名：American Journal of Obstetrics and Gynecology
- 出版年：2010
- 出版时间：August 2010
- 年：2010
- 卷：203
- 期：2
- 页码：105.e1-105.e13
- 全文大小：1280 K
ass=""h4"">Objective
The purpose of this study was to compare clinical outcome and health related quality of life (HRQOL) 5 years after uterine artery embolization (UAE) or hysterectomy in the treatment of menorrhagia caused by uterine fibroids.ass=""h4"">Study Design
Patients with symptomatic uterine fibroids who were eligible for hysterectomy were assigned randomly 1:1 to hysterectomy or UAE. Endpoints after 5 years were reintervention rates, menorrhagia, and HRQOL measures that were assessed by validated questionnaires.
ass=""h4"">Results
Patients were assigned randomly to UAE (n = 88) or hysterectomy (n = 89). Five years after treatment 23 of 81 UAE patients (28.4 % ) had undergone a hysterectomy because of insufficient improvement of complaints (24.7 % after successful UAE). HRQOL measures improved significantly and remained stable until the 5-year follow-up evaluation, with no differences between the groups. UAE had a positive effect both on urinary and defecation function.
ass=""h4"">Conclusion
UAE is a well-established alternative to hysterectomy about which patients should be counseled.