A Pilot Study of the Tolerability and Effects of High-Definition Transcranial Direct Current Stimulation (HD-tDCS) on Pain Perception

详细信息    查看全文

• 作者：Jeffrey J. Borckardt^&lowast ; ; ^&dagger ; ; ^{borckard@musc.edu} ; Marom Bikson^&Dagger ; ; Heather Frohman^&lowast ; ; Scott T. Reeves^&dagger ; ; Abhishek Datta^&Dagger ; ; Varun Bansal^&Dagger ; ; Alok Madan^&lowast ; ; Kelly Barth^&lowast ; ; Mark S. George^&lowast ; ; ^§ ;
• 关键词：tDCS ; HD-tDCS ; pain ; TMS ; MCS ; electrical brain stimulation
• 刊名：The Journal of Pain
• 出版年：2012
• 出版时间：February 2012
• 年：2012
• 卷：13
• 期：2
• 页码：112-120
• 全文大小：1099 K

文摘

Several brain stimulation technologies are beginning to evidence promise as pain treatments. However, traditional versions of 1 specific technique, transcranial direct current stimulation (tDCS), stimulate broad regions of cortex with poor spatial precision. A new tDCS design, called high definition tDCS (HD-tDCS), allows for focal delivery of the charge to discrete regions of the cortex. We sought to preliminarily test the safety and tolerability of the HD-tDCS technique as well as to evaluate whether HD-tDCS over the motor cortex would decrease pain and sensory experience. Twenty-four healthy adult volunteers underwent quantitative sensory testing before and after 20 minutes of real (n = 13) or sham (n = 11) 2 mA HD-tDCS over the motor cortex. No adverse events occurred and no side effects were reported. Real HD-tDCS was associated with significantly decreased heat and cold sensory thresholds, decreased thermal wind-up pain, and a marginal analgesic effect for cold pain thresholds. No significant effects were observed for mechanical pain thresholds or heat pain thresholds. HD-tDCS appears well tolerated, and produced changes in underlying cortex that are associated with changes in pain perception. Future studies are warranted to investigate HD-tDCS in other applications, and to examine further its potential to affect pain perception.

Perspective

This article presents preliminary tolerability and efficacy data for a new focal brain stimulation technique called high definition transcranial direct current stimulation. This technique may have applications in the management of pain.