Metabolite profiles of rats in repeated dose toxicological studies after oral and inhalative exposure
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- 作者：E. Fabiana ; eric.fabian@basf.com" class="auth_mail" title="E-mail the corresponding author ; N. Bordagb ; natalie@bordag.com" class="auth_mail" title="E-mail the corresponding author ; M. Heroldb ; michael.herold@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; H. Kampa ; G. Krennrichc ; gerhard.krennrich@basf.com" class="auth_mail" title="E-mail the corresponding author ; R. Looserb ; d ; ralf.looser@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; L. Ma-Hocka ; lan.ma-hock@basf.com" class="auth_mail" title="E-mail the corresponding author ; W. Mellerta ; werner.mellert@basf.com" class="auth_mail" title="E-mail the corresponding author ; G. Montoyaa ; Gina.MONTOYAPARRA@danone.com" class="auth_mail" title="E-mail the corresponding author ; E. Peterb ; erik.peter@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; A. Prokudinb ; alexander.prokudin@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; M. Spitzerb ; michael.spitzer@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; V. Straussa ; volker.strauss@basf.com" class="auth_mail" title="E-mail the corresponding author ; T. Walkb ; tilmann.walk@metanomics.de" class="auth_mail" title="E-mail the corresponding author ; R. Zbraneka ; rene.zbranek@basf.com" class="auth_mail" title="E-mail the corresponding author ; B. van Ravenzwaaya ; bennard.ravenzwaay@basf.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：A ; aniline ; CL ; chloroform ; DMF ; N ; N-dimethylformamide ; EB ; ethylbenzene ; LOAEL ; lowest observed adverse effect level ; PWC ; pairwise comparison ; ME ; 2-methoxyethanol ; MoA ; mode of action ; MTD ; maximum-tolerated dose ; THF ; tetrahydrofurane
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：25 July 2016
- 年：2016
- 卷：255
- 期：Complete
- 页码：11-23
- 全文大小：1214 K
文摘
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Comparison of metabolic profiles in rat plasma after repeated inhalative and oral exposure for 6 toxicants with known toxicological mode of action.
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Route of exposure dependent metabolic response for toxicants with weak metabolome changes (low profile strengths) e.g. female rats dosed inhalatively with Aniline or Tetrahydrofurane.
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Route of exposure independent metabolic response for toxicants with profound metabolome changes (high profile strengths), e.g. rats dosed with chloroform or 2-methoxyethanol.
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Link of inhalatively tested compounds to MetaMap®-Tox database with plasma-metabolome and toxicity data of rats for more than 550 reference compounds, dosed orally in an adapted OECD 407 protocol.