A data-driven weighting scheme for multivariate phenotypic endpoints recapitulates zebrafish developmental cascades

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• 作者：Guozhu Zhang^a ; ^{gzhang6@ncsu.edu} ; Kyle R. Roell^a ; ^{krroell@ncsu.edu} ; Lisa Truong^c ; ^{lisa.truong@oregonstate.edu} ; Robert L. Tanguay^c ; ^{robert.tanguay@oregonstate.edu} ; David M. Reif^a ; ^b ; ^{dmreif@ncsu.edu}
• 关键词：AC50 ; half-maximal activity concentration ; AOP ; Adverse Outcome Pathway ; AggE ; Aggregate Entropy ; EZ ; embryonic zebrafish ; HTS ; high-throughput screening ; Hpf ; hours post fertilization ; LD50 ; 50% lethal dose ; MoA ; mechanisms of action ; POD ; point of departure ; ROC ; Receiver Operating Characteristic ; ToxRefDB ; Toxicity Reference Database ; wAggE ; weighted Aggregate Entropy ; TN ; true negative ; TP ; true positive ; FN ; false negative ; FP ; false negative ; MORT ; mortality ; YSE ; yolk sac edema ; AXIS ; bod
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2017
• 出版时间：1 January 2017
• 年：2017
• 卷：314
• 期：Complete
• 页码：109-117
• 全文大小：1543 K
• 卷排序：314

文摘

Introduced a data-driven weighting scheme for multiple phenotypic endpoints. Weighted Aggregate Entropy (wAggE) implies differential importance of endpoints. Endpoint relationships reveal developmental cascade effects triggered by exposure. wAggE is generalizable to multi-endpoint data of different shapes and scales.