Laminated electrospun nHA/PHB-composite scaffolds mimicking bone extracellular matrix for bone tissue engineering

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• 作者：Zhuoyue Chen^a ; ^b ; ¹ ; Yue Song^a ; ¹ ; Jing Zhang^a ; ^b ; ^c ; Wei Liu^a ; Jihong Cui^a ; ^b ; ^c ; ^{cjh@nwu.edu.cn} ; Hongmin Li^a ; ^b ; ^c ; Fulin Chen^a ; ^b ; ^c
• 关键词：Electrospinning ; PHB ; nHA ; Laminated technology ; Bone tissue engineering
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 March 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：341-351
• 全文大小：1904 K
• 卷排序：72

文摘

We laminated the nHA/PHB layers to obtain a scaffold for bone tissue engineering. The laminated scaffold performed optimized cell-loading capacity. MSCs exhibited osteogenic phenotypes on the laminated scaffold. Osteoid tissue formed throughout the laminated scaffold after 2 months in vivo.The laminated bio-composite scaffolds can be applied to bone regeneration.