Molecular, cellular and functional events in axonal sprouting after stroke

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• 作者：S. Thomas Carmichael ; ^{scarmichael@mednet.ucla.edu} ; Balachandar Kathirvelu ^{bkathirvelu@ucla.edu} ; Catherine A. Schweppe ^{caschweppe@ucla.edu} ; Esther H. Nie ^{EstherNie@mednet.ucla.edu}
• 关键词：Rehabilitation ; Regeneration ; Recovery ; Spinal cord ; Cortex ; GDF10 ; TGFβ ; Astrocyte ; Behavior
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：287
• 期：part_P3
• 页码：384-394
• 全文大小：1246 K
• 卷排序：287

文摘

Stroke induces the formation of new connections in brain and spinal cord. These mediate some aspects of motor recovery. A unique molecular program, a regenerative transcriptome, underlies post-stroke axonal sprouting. Axonal sprouting occurs in three different patterns: reactive, reparative and unbounded. Each pattern of post-stroke axonal sprouting has unique relationships to behavioral activity and molecular control points.