Toward the validation of a new method (MUNIX) for motor unit number assessment

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• 作者：Franziska SteinAuthor Vitae ; Ines KoborAuthor Vitae ; Ulrich BogdahnAuthor Vitae ; Wilhelm J. Schulte-Mattler ; ^{wilhelm.schulte-mattler@klinik.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author}Author Vitae
• 关键词：ADM ; abductor digiti minimi muscle ; ALS ; amyotrophic lateral sclerosis ; CMAP ; compound muscle action potential ; IS-MUNE ; incremental stimulation motor unit number estimation ; MU ; motor unit ; MUAP ; motor unit action potential ; MUNE ; motor unit number estimation ; MUNIX ; motor unit number index ; SD ; standard deviation ; SIP ; surface interference pattern ; SMUP ; single motor unit potential ; STA-MUNE ; spike-triggered averaging motor unit number estimation
• 刊名：Journal of Electromyography and Kinesiology
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：27
• 期：Complete
• 页码：73-77
• 全文大小：450 K

文摘

Introduction: This prospectively designed study analyzed the correlation of a new, non-invasive neurophysiological method (Motor Unit Number Index – MUNIX) with two established Motor Unit Number Estimation (MUNE) methods. Methods: MUNIX and incremental stimulation MUNE (IS-MUNE) were done in the abductor digiti minimi muscle (ADM), while MUNIX and spike-triggered averaging MUNE (STA-MUNE) were tested in the trapezius muscle. Twenty healthy subjects and 17 patients with amyotrophic lateral sclerosis (ALS) were examined. Results: MUNIX and MUNE values correlated significantly (ADM: n = 108; Spearman-Rho; r = 0.88; p < 0.01; trapezius muscle: n = 49; Spearman-Rho; r = 0.46; p < 0.01). Discussion: MUNIX indeed reflects the number of motor units in a muscle, and may sensibly be recorded from the trapezius muscle. With MUNIX being both much more patient friendly and much more rapid to assess than MUNE, the results support the use of MUNIX when motor unit number assessment is desired.