Characteristics of immune memory 10-15 years after primary hepatitis B vaccination
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- 作者：Irena Brunskole Hummela ; irena.hummel@klinik.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author ; Anita Zitzmanna ; anita-zitzmann@t-online.de" class="auth_mail" title="E-mail the corresponding author ; Monika Erla ; monika.erl@klinik.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author ; Jü ; rgen J. Wenzelb ; juergen.wenzel@klinik.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author ; Wolfgang Jilga ; wolfgang.jilg@klinik.uni-regensburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：ELISpot ; enzyme-linked immunospot assay ; HBsAg ; hepatitis B surface antigen ; HBV ; hepatitis B virus ; IFNγ ; interferon γ ; IL5 ; interleukin 5 ; PBMC ; peripheral blood mononuclear cells ; SFC ; spot forming cells ; Th1 ; T helper 1 ; Th2 ; T helper 2
- 刊名：Vaccine
- 出版年：2016
- 出版时间：27 January 2016
- 年：2016
- 卷：34
- 期：5
- 页码：636-642
- 全文大小：708 K
文摘
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B cell memory was present in 22/23 subjects after hepatitis B booster vaccination.
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Typical anamnestic response curves were seen, also by anti-HBs remaining <10 IU/l.
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T cell responses were detectable in 18%, 48% and 57% at day 0, 7 and 28 post-booster.
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Kinetic patterns of T cell responses differed considerably between subjects.