Clinicopathologic features of early lesions of primary cutaneous follicle center lymphoma, diffuse type: Implications for early diagnosis and treatment

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• 作者：Andrea  ; Gulia MD^a ;   ; ^b ; Andrea  ; Saggini MD^a ;   ; ^c ; Thomas  ; Wiesner MD^a ; Regina  ; Fink-Puches MD^a ; Zsolt  ; Argenyi MD^d ; Gerardo  ; Ferrara MD^e ; Cornelia S.L.  ; Mü ; ller MD^f ; Esmeralda  ; Vale MD^g ; Lorenzo  ; Cerroni MD^a ;   ; ^{lorenzo.cerroni@medunigraz.at}
• 关键词：Crosti lymphoma ; cutaneous lymphoma ; early diagnosis ; fluorescence in situ hybridization ; primary cutaneous B-cell lymphoma ; primary cutaneous follicle center lymphoma
• 刊名：Journal of the American Academy of Dermatology
• 出版年：2011
• 出版时间：November 2011
• 年：2011
• 卷：65
• 期：5
• 页码：991-1000.e7
• 全文大小：6028 K

文摘

Background

Data on early lesions of primary cutaneous follicle center lymphoma (PCFCL), diffuse type are very limited.

Objective

We sought to elucidate the early clinicopathologic features of PCFCL, diffuse type.

Methods

Clinical, histologic, immunohistologic, molecular, and fluorescence in situ hybridization data from 24 patients with early lesions of PCFCL, diffuse type (male:female?= 19:5; median age: 57 years) were determined.

Results

Lesions consisted mostly of solitary or clustered papules and small nodules located on the trunk (21 cases), arm (two cases), and scalp (one case). In 3 patients small papules were located at a distance from the main affected area. All biopsy specimens from early lesions showed aggregates of medium and large centrocytes admixed with small lymphocytes without formation of clear-cut lymph follicles. Staining for Bcl-2 was positive in only 7 cases, one revealing also a rearranged BCL2 signal by fluorescence in situ hybridization. Data on treatment and follow-up were available for 22 patients. At last examination 13 patients were in complete remission (median follow-up: 60 months), 6 were alive with skin disease alone (median follow-up: 60 months), two were alive with skin disease and bone-marrow or lymph node involvement, respectively, and one died of unrelated causes while in complete remission.

Limitations

The retrospective study and the fact that patients were treated at different institutions are limitations.

Conclusions

Early lesions of PCFCL, diffuse type present with characteristic clinicopathologic features. Dermatologists should be alert particularly to the early clinical manifestations of this lymphoma and to the presence of small, inconspicuous lesions at a distance from the main affected area in order to plan treatment properly.