Genomic profile in gestational and non-gestational choriocarcinomas

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• 作者：Julia Bette Homem de Mello^a ; Priscila Daniele Ramos Cirilo^b ; Odair Carlito Michelin^c ; Maria Aparecida Custó ; dio Domingues^d ; Marilza Vieira Cunha Rudge^e ; Silvia Regina Rogatto^f ; ^g ; ¹ ; ^{silvia.regina.rogatto@rsyd.dk} ; ^{rogatto@fmb.unesp.br} ; Izildinha Maestá ; ^e ; ¹
• 关键词：Gestational choriocarcinoma ; Non-gestational choriocarcinoma ; Microsatellites ; Array comparative genomic hybridization ; Copy number alteration
• 刊名：Placenta
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：50
• 期：Complete
• 页码：8-15
• 全文大小：2923 K
• 卷排序：50

文摘

The majority of GC and NGC showed previous history of hydatiform mole. GC and NGC present different genomic profiles by aCGH. Recurrent losses involving CDH19 and TRIM32 were detected in GC. Gains of 17q25 (CBX2, CBX4 and CBX8) were preferentially found in high risk prognostic score in GC. In silico analysis revealed the involvement of PTEN and PI3K-Akt pathways in GC.