Analysis of 4-bromo-3-fluorobenzaldehyde and separation of its regioisomers by one-dimensional and two-dimensional gas chromatography
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- 作者：Bo Shena ; bshen@amgen.com" class="auth_mail" title="E-mail the corresponding author ; bshen@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; David Semina ; Jan Fangb ; Gary Guoc
- 关键词：GC ; μ-ECD ; Deans switch ; 1D-GC ; 2D-GC ; Chiral GC column ; regioisomers ; p-GTI
- 刊名：Journal of Chromatography A
- 出版年：2016
- 出版时间：2 September 2016
- 年：2016
- 卷：1462
- 期：Complete
- 页码：115-123
- 全文大小：1931 K
文摘
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Two methods were developed for regioisomer impurity control in API.
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Very unique resolution of chiral GC column for the 10 regioisomers was utilized.
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2D-GC method was developed for the separation of the ten regioisomers.
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μ-ECD detector achieved the best LOQ of the ten regioisomers.
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The methods were validated for p-GTI control in trace level in API.