Obstetric and Neonatal Adversities, Parity, and Tourette Syndrome: A Nationwide Registry

详细信息    查看全文

• 作者：Susanna Leivonen ; MD¹ ; ² ; ^{susanna.leivonen@utu.fi" class="auth_mail" title="E-mail the corresponding author} ; Arja Voutilainen ; MD² ; Roshan Chudal ; PhD¹ ; Auli Suominen ; MSc¹ ; Mika Gissler ; PhD³ ; ⁴ ; Andre Sourander ; MD¹ ; ⁵ ; ⁶
• 关键词：ADHD ; Attention deficit hyperactivity disorder ; ALSPAC ; Avon Longitudinal Study of Parents and Children ; ASD ; Autism spectrum disorder ; FHDR ; Finnish Hospital Discharge Register ; FMBR ; Finnish Medical Birth Register ; ICD ; International Classification of Diseases ; ICD-10 ; ICD Tenth Revision ; ICD-9 ; ICD Ninth Revision ; SES ; Socioeconomic status
• 刊名：The Journal of Pediatrics
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：171
• 期：Complete
• 页码：213-219
• 全文大小：257 K

文摘

To determine the relationships between parity, obstetric adversities, neonatal factors, and Tourette syndrome in a large nationwide cohort.

Study design

This nationwide, register-based, nested case-control study identified all children diagnosed with Tourette syndrome born between 1991 and 2010 from the Finnish Hospital Discharge Register (n = 767). Each case was matched to 4 controls. Information on parity, obstetric, and neonatal factors was obtained from the Finnish Medical Birth Register. Conditional logistic regression was used to determine the relationship between parity, obstetric, and neonatal factors, and Tourette syndrome.

Results

Nulliparity was associated with increased odds for Tourette syndrome (OR 1.7, 95% CI 1.4-2.2), and 3 or more previous births was associated with decreased odds for Tourette syndrome (OR 0.5, 95% CI 0.3-0.9) compared with parity 1-2. Birth weight 4000-4499 g was associated with decreased odds for Tourette syndrome (OR 0.7, 95% CI 0.5-0.9). Low birth weight, gestational age, weight for gestational age, Apgar score at 1 minute, induced labor, birth type or presentation, neonatal treatment, or maternal blood pressure were not associated with Tourette syndrome.

Conclusions

Increasing parity and high birth weight are associated with decreased odds for Tourette syndrome.