TAM up-regulated the expression of GRP78 in MCF-7 and MDA-MB-231 cells.
Inhibition of GRP78 augmented TAM-induced apoptosis.
TAM selectively up-regulated AKT(thr308) levels but not AKT(ser473).
Silencing of GRP78 inhibited AKT phosphorylation at thr308 but not at ser473.
TAM also induced phosphorylation of GSK3β, a downstream substrate of AKT.