Tamoxifen-induced cytotoxicity in breast cancer cells is mediated by glucose-regulated protein 78 (GRP78) via AKT (Thr308) regulation
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- 作者：Radha Pujaria ; Jemy Josea ; Varsha Bhavnania ; Natesh Kumarb ; Padma Shastryb ; padma@nccs.res.in" class="auth_mail" title="E-mail the corresponding author ; Jayanta K. Pala ; jkpal@unipune.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：GRP78 ; glucose-regulated protein 78 ; UPR ; unfolded protein response ; TAX ; paclitaxel ; DOX ; doxorubicin ; 5-FU ; 5 fluorouracil ; TAM ; tamoxifen ; ER ; estrogen receptor
- 刊名：International Journal of Biochemistry and Cell Biology
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：77
- 期：part_PA
- 页码：57-67
- 全文大小：3049 K
文摘
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TAM up-regulated the expression of GRP78 in MCF-7 and MDA-MB-231 cells.
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Inhibition of GRP78 augmented TAM-induced apoptosis.
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TAM selectively up-regulated AKT(thr308) levels but not AKT(ser473).
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Silencing of GRP78 inhibited AKT phosphorylation at thr308 but not at ser473.
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TAM also induced phosphorylation of GSK3β, a downstream substrate of AKT.