The inhibitory mechanism by curcumin on the Zac1-enhanced cyclin D1 expression in human keratinocytes
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- 作者：Chih-Tsung Hunga ; Shih-Ming Huangb ; Hsiao-Chun Chengb ; Shu-Ting Liub ; Yung-Lung Changb ; Ying-Chun Liuc ; d ; Wei-Ming Wanga ; b ; ades0431@ms38.hinet.net" class="auth_mail" title="E-mail the corresponding author
- 关键词：Zac1 ; a zinc-finger protein which regulates cell cycle arrest and apoptosis 1 ; pRb ; Retinoblastoma protein ; CDKs ; cyclin-dependent kinases ; AP-1 ; activator protein-1 ; RLU ; relative light units ; ACTN ; 伪-actinin ; RT-PCR ; reverse transcription- polymerase chain reaction ; FACS ; fluorescence-activated cell sorting
- 刊名：Journal of Dermatological Science
- 出版年：2015
- 出版时间：September 2015
- 年：2015
- 卷：79
- 期：3
- 页码：262-267
- 全文大小：859 K
文摘
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Zac1 enhances the expression of cyclin D1.
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Curcumin decreases both the expression of cyclin D1 and Zac1.
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Curcumin prevents keratinocytes from entry into S phase in the cell cycle.