Mitogen-activated protein kinases as key players in osmotic stress signaling
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- 作者：Xiangyu Zhou ; Isao Naguro ; Hidenori Ichijo ; Kengo Watanabe
- 关键词：Mitogen-activated protein kinase ; Osmotic stress ; Regulatory volume decrease ; Regulatory volume increase ; Apoptosis signal-regulating kinase 3 ; With-no-lysine kinase
- 刊名：Biochimica et Biophysica Acta (BBA) - General Subjects
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1860
- 期：9
- 页码：2037-2052
- 全文大小：1057 K
文摘
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Osmotic stress causes cell swelling or shrinkage and has deleterious effects on cellular activities.
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10">Cells can adapt to anisosmotic conditions by regulating the intracellular content of inorganic ions and organic osmolytes.
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15">Mitogen-activated protein kinases (MAPKs) play central roles in osmotic stress signaling.
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Apoptosis signal-regulating kinase 3 exhibits a unique responsiveness to osmotic stress and has potential importance in osmoregulation.
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Studies regarding the upstream factors of MAPK pathways will contribute to reveal the mechanism by which mammalian cells sense osmotic stress.