TNFAIP3, a negative regulator of the TLR signaling pathway, is a potential predictive biomarker of response to antidepressant treatment in major depressive disorder

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• 作者：Yi-Yung Hung^a ; ^b ; Chin-Chuen Lin^a ; Hong-Yo Kang^b ; ^c ; ¹ ; ^{a540520@adm.cgmh.org} ; ^{hkang3@mail.cgu.edu.tw} ; Tiao-Lai Huang^a ; ¹ ;
• 关键词：Negative regulation ; Toll-like receptor ; Innate immunity ; Major depressive disorder ; Inflammation ; Antidepressants
• 刊名：Brain, Behavior, and Immunity
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：59
• 期：Complete
• 页码：265-272
• 全文大小：482 K
• 卷排序：59

文摘

The gene expression profiles of negative regulators of the TLR signaling were low in major depressive disorder. TNFAIP3 expression was inversely associated with severity of depression. Fluoxetine, an antidepressant, directly increased TNFAIP3 gene expression in monocytes and microglia cell lines. TNFAIP3 predicted response of antidepressants treatment.