Histone modifications in FASN modulated by sterol regulatory element-binding protein 1c and carbohydrate responsive-element binding protein under insulin stimulation are related to NAFLD

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• 作者：Xuan Du ; Can Cai ; Jialing Yao ; Youping Zhou ; Huihong Yu ; Wei Shen ; ^{shenwei315@126.com}
• 关键词：Histone modification ; SREBP-1c ; ChREBP ; NAFLD ; IR ; Hepatocyte steatosis
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：29 January 2017
• 年：2017
• 卷：483
• 期：1
• 页码：409-417
• 全文大小：2723 K
• 卷排序：483

文摘

Insulin induced FASN transcription was accompanied by local histone modification. SREBP-1c and ChREBP could affect histone modification of the FASN gene in the setting of high insulin levels. Histone acetylation affects FASN transcription by influencing transcription factor and target gene binding. Reveal the potential importance of the transcription factor ChREBP in NAFLD.