c-FLIP Expression in Foxp3-Expressing Cells Is Essential for Survival of Regulatory T Cells and Prevention of Autoimmunity

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• 作者：Carlos Plaza-Sirvent¹ ; ² ; Marc Schuster¹ ; ² ; Yvonne Neumann¹ ; ² ; Ulrike Heise³ ; Marina C. Pils³ ; Klaus Schulze-Osthoff⁴ ; ⁵ ; Ingo Schmitz¹ ; ² ; ⁶ ; ^{ingo.schmitz@helmholtz-hzi.de}
• 关键词：apoptosis ; c-FLIP ; Cflar ; regulatory T cell
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：12-22
• 全文大小：3167 K
• 卷排序：18

文摘

Treg cells exhibit a high rate of apoptosis ex vivo Treg cells express lower levels of c-FLIPL than Tcon Treg-specific deletion of Cflar/c-FLIP results in a scurfy-like phenotype c-FLIP has additional functions in Treg cells than inhibition of CD95