Variable neighborhood search for reverse engineering of gene regulatory networks

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• 作者：Charles Nicholson^a ; ^{cnicholson@ou.edu} ; Leslie Goodwin^a ; ^{leslie.goodwin@ou.edu} ; Corey Clark^b ; ^{coreyc@smu.edu}
• 关键词：Gene regulatory networks ; Reverse engineering ; Variable neighborhood search
• 刊名：Journal of Biomedical Informatics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：65
• 期：Complete
• 页码：120-131
• 全文大小：956 K
• 卷排序：65

文摘

A search heuristic is proposed for reverse engineering of gene regulatory networks. The approach is based on the variable neighborhood search metaheuristic. Search neighborhood structures are defined based on permissible move types. Empirically it outperforms greedy techniques in both speed and solution quality.