Regulation, Signaling, and Physiological Functions of G-Proteins
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- 作者：Viktoriya Syrovatkina ; Kamela O. Alegre ; Raja Dey ; Xin-Yun Huang ; xyhuang@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：GPCR ; G-protein-coupled receptor ; G-protein ; guanine-nucleotide-binding regulatory proteins ; β2-AR ; β2-adrenergic receptor ; GPR ; G-protein regulator ; GBA ; Gα-binding and activating ; RGS ; regulators of G-protein signaling ; RTK ; receptor tyrosine kinase ; GEF ; guanine nucleotide exchange factor ; GAP ; GTPase-activating protein ; TM ; transmembrane ; β1-AR ; β1-adrenergic receptor ; GIV ; Gα-interacting-vesicle-associated protein ; IP3 ; inositol trisphosphate ; DAG ; diacylglycerol ; PDGF ; platelet-derived gro
- 刊名：Journal of Molecular Biology
- 出版年：2016
- 出版时间：25 September 2016
- 年：2016
- 卷：428
- 期：19
- 页码：3850-3868
- 全文大小：2411 K
文摘
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Heterotrimeric G-proteins can be regulated by GPCRs and by non-receptor proteins such as Ric-8, G-protein regulator, and regulators of G-protein signaling proteins.
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Many proteins interacting with G-proteins have been identified.
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G-proteins regulate various physiological functions.
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Combinations of structural and computational biological tools can be used to understand the mechanisms of activation of G-proteins by GPCRs and non-GPCR regulators. Multidisciplinary studies are needed to systematically investigate the biochemical mechanisms, cellular effects, and physiological functions in processes involving apparently non-canonical G-protein signaling.