Glucagon-like Peptide 1 Receptor Signaling in Acinar Cells Causes Growth-Dependent Release of Pancreatic Enzymes

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• 作者：Nicolai J. Wewer Albrechtsen¹ ; ² ; ⁶ ; Reidar Albrechtsen³ ; ⁶ ; Lasse Bremholm⁴ ; Berit Svendsen¹ ; ² ; Rune E. Kuhre¹ ; ² ; Steen S. Poulsen¹ ; ² ; Charlotte B. Christiansen¹ ; ² ; Elisa P. Jensen¹ ; ² ; Charlotte Janus¹ ; ² ; Linda Hilsted⁵ ; Carolyn F. Deacon¹ ; ² ; Bolette Hartmann¹ ; ² ; Jens J. Holst¹ ; ² ; ⁷ ; ^{jjholst@sund.ku.dk}
• 关键词：acinar cells ; amylase ; GLP-1 ; GLP-1R ; lipase ; pancreatic enzymes
• 刊名：Cell Reports
• 出版年：2016
• 出版时间：13 December 2016
• 年：2016
• 卷：17
• 期：11
• 页码：2845-2856
• 全文大小：4167 K
• 卷排序：17

文摘

Glucagon-like peptide 1 does not acutely increase amylase and lipase levels Glucagon-like peptide 1 induces mild c-Src-dependent acinar cell proliferation This proliferation is associated with an increased constitutive release of enzymes Enzyme increase during GLP-1 treatment does not reflect sub-clinical pancreatitis