Intramolecular cyanoamidation of unsaturated cyanoformamides catalyzed by palladium: an efficient synthesis of multi-functionalized lactams

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• 作者：Yusuke Kobayashi ; Haruhi Kamisaki ; Hiroshi Takeda ; Yoshizumi Yasui ; Reiko Yanada ; Yoshiji Takemoto
• 刊名：Tetrahedron
• 出版年：2007
• 出版时间：2 April 2007
• 年：2007
• 卷：63
• 期：14
• 页码：2978-2989
• 全文大小：801 K

文摘

The Pd(0)-catalyzed intramolecular cyanoamidation of several unsaturated cyanoformamides with alkenyl, allenyl, and alkynyl groups was investigated. In the cases of alkynyl and 1,1-disubstituted alkenyl cyanoformamides, the Pd(0)-catalyzed C–CN activation and subsequent insertion reaction proceeded smoothly and gave the corresponding lactams bearing a cyano group at the β-position in good yields. The mechanism of the reaction was also discussed.