- 作者：S. Onga ; S.-W. Kanga ; kswnephrology@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Y.-H. Kima ; T.-H. Kima ; K.-H. Jeongb ; S.-K. Kimc ; Y.-C. Yoond ; S.-K. Seoe ; J.-Y. Moonb ; S.-H. Leeb ; C.-G. Ihmb ; T.-W. Leeb ; J.-H. Chungc
- 刊名：Transplantation Proceedings
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：48
- 期：3
- 页码：858-863
- 全文大小：477 K
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New-onset diabetes after transplantation is a serious metabolic complication that may follow renal transplantation.
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We examined the association between NODAT and 11 SNPs located within the 3 genes of MMPs that might be related to NODAT.
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A total of 309 renal transplant recipients without a history of diabetes were included in this study. We analyzed the association between the development of NODAT and a panel of 11 SNPs within 3 MMP genes. Two of the 11 (18.1%) SNPs were significantly associated with NODAT development after adjusting for age, sex, and tacrolimus usage: MMP-2 (rs1132896) and MMP-2 (rs243849). In the multiple logistic regression analysis, these 2 SNPs were significantly associated with the development of NODAT. MMP-2 gene rs1132896 and rs243849 polymorphisms may serve as genetic markers for the development of NODAT.