Imidazopyridine-fused [1,3]-diazepinones part 2: Structure-activity relationships and antiproliferative activity against melanoma cells

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• 作者：Virginie Bellet ; Laure Lichon ; Dominique P. Arama ; Audrey Gallud ; Vincent Lisowski ; Ludovic T. Maillard ; Marcel Garcia ; Jean Martinez ; Nicolas Masurier ; ^{nicolas.masurier@umontpellier.fr}
• 关键词：Imidazo[1 ; 2-a]pyridine ; Polyfused heterocycles ; Diazepinones ; Antitumor activity ; Melanoma
• 刊名：European Journal of Medicinal Chemistry
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：125
• 期：Complete
• 页码：1225-1234
• 全文大小：1056 K
• 卷排序：125

文摘

28 novel pyrido-imidazodiazepinone derivatives were synthesized. SAR studies of position 2, 3, 4 and 5 of the diazepine core were performed. Their cytotoxicities were evaluated against the melanoma MDA-MB-435 cell line. Several compounds showed a specificity against the melanoma MDA-MB-435 cell line.