Polymeric nanoparticles - Influence of the glass transition temperature on drug release
详细信息 查看全文
- 作者：Svenja Lappe ; Dennis Mulac ; Klaus Langer ; k.langer@wwu.de
- 关键词：Drug delivery system ; Poly (DL-lactic-co-glycolic acid) ; Poly (lactic acid) ; Differential scanning calorimetry ; Release profile
- 刊名：International Journal of Pharmaceutics
- 出版年：2017
- 出版时间：30 January 2017
- 年：2017
- 卷：517
- 期：1-2
- 页码：338-347
- 全文大小：1021 K
- 卷排序：517
文摘
The physico-chemical characterisation of nanoparticles is often lacking the determination of the glass transition temperature, a well-known parameter for the pure polymer carrier. In the present study the influence of water on the glass transition temperature of poly (DL-lactic-co-glycolic acid) nanoparticles was assessed. In addition, flurbiprofen and mTHPP as model drugs were incorporated in poly (DL-lactic-co-glycolic acid), poly (DL-lactic acid), and poly (L-lactic acid) nanoparticles. For flurbiprofen-loaded nanoparticles a decrease in the glass transition temperature was observed while mTHPP exerted no influence on this parameter.Based on this observation, the release behaviour of the drug-loaded nanoparticles was investigated at different temperatures. For all preparations an initial burst release was measured that could be attributed to the drug adsorbed to the large nanoparticle surface. At temperatures above the glass transition temperature an instant drug release of the nanoparticles was observed, while at lower temperatures less drug was released. It could be shown that the glass transition temperature of drug loaded nanoparticles in suspension more than the corresponding temperature of the pure polymer is the pivotal parameter when characterising a nanostructured drug delivery system.