Histone deacetylase inhibition prevents the impairing effects of hippocampal gastrin-releasing peptide receptor antagonism on memory consolidation and extinction
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- 作者：Fernanda S. Petrya ; b ; Arethuza S. Dornellesa ; b ; Martina Lichtenfelsa ; b ; Fernanda E. Valiatia ; b ; Caroline Brunetto de Fariasa ; c ; Gilberto Schwartsmanna ; d ; Marise B. Parente ; Rafael Roeslera ; b ; rafael.roesler@pq.cnpq.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Gastrin-releasing peptide receptor ; Histone deacetylase ; Brain-derived neurotrophic factor ; Hippocampus ; Memory consolidation ; Memory extinction
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 July 2016
- 年：2016
- 卷：307
- 期：Complete
- 页码：46-53
- 全文大小：1470 K
文摘
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Intrahippocampal sodium butyrate prevented the memory loss induced by GRPR antagonism.
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Inhibiting both HDAC and GRPR in the hippocampus increased BDNF levels.
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HDAC inhibition protects against hippocampal memory impairment by GRPR blockade.