Intravenous immunoglobulin treatment in the prevention of childbirth-associated acute exacerbations in multiple sclerosis - A pilot study.

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• 作者：Achiron ; A. ; Rotstein ; Z. ; Noy ; S. ; Mashiach ; S. ; Dulitzky ; M. ; Achiron ; R.
• 刊名：Journal of Neuroimmunology
• 出版年：1995
• 出版时间：1995
• 年：1995
• 卷：56
• 期：971
• 页码：56
• 全文大小：102 K

文摘

Acute exacerbations frequently occur after childbirth in relapsing-remitting multiple sclerosis (MS) patients. The present pilot study was initiated in an attempt to reduce the number of childbirth- associated acute exacerbations in the postpartum period. We treated 9 MS patients with a history of twelve childbirth-associated acute exacerbations that had occurred 2 to 9 weeks after previous deliveries, with intravenous immunoglobulin (IVIg), at a dose of 0.4 gr/kg/day for 5 consecutive days during the first week after childbirth and at 6 and 12 weeks thereafter. None of the treated patients relapsed during the 6 month period after delivery. Three patients had a remote relapse, two at 8 months and one patient at 10 months after childbirth, probably representing the natural course of disease and not associated with childbirth. We conclude that IVIg treatment may serve as a potential treatment to prevent acute childbirth-associated exacerbations in relapsing-remitting MS patients.