Free radical scavenging injectable hydrogels for regenerative therapy

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• 作者：Remya Komeri^a ; Finosh Gnanaprakasam Thankam^b ; Jayabalan Muthu^a ; ^{mjayabalan52@gmail.com}
• 关键词：Pathological free radicals ; Injectable hydrogel ; Regenerative therapy ; Free radical scavenging ; Antioxidant
• 刊名：Materials Science and Engineering: C
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：71
• 期：Complete
• 页码：100-110
• 全文大小：1873 K
• 卷排序：71

文摘

Novel injectable hydrogel (PEAX-P) is prepared using D-xylitol-co-fumarate-co-poly ethylene adipate-co-PEG comaromer. The PEAX-P hydrogel has suitable swelling, mechanical and degradation characterestics for injectable myocardial therapy. The PEAX-P hydrogel scavenge 51% DPPH radical, 40% hydroxyl radicals and 41% nitrate radicals. The in vitro studies confirm the protective effect of the present hydrogel on cardiomyoblast cells under oxidative stress. The free electrons, hydrogen atoms and free water are responsible for the free radical scavenging property of hydrogel. The present hydrogel is a potential candidate for myocardial regenerative therapy even with hypoxic microenvironment.