Progression of Renal Impairment and Chronic Kidney Disease in Chronic Heart Failure: An Analysis From GISSI-HF

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• 作者：Kevin Damman ; MD ; PhD¹ ; ^{k.damman@umcg.nl} ; Serge Masson ; PhD² ; Donata Lucci ; MSc³ ; Marco Gorini ; MS³ ; Renato Urso ; PhD⁴ ; Aldo P. Maggioni ; MD³ ; Luigi Tavazzi ; MD⁵ ; Luigi Tarantini ; MD⁶ ; Gianni Tognoni ; MD² ; Adriaan Voors ; MD ; PhD¹ ; Roberto Latini ; MD²
• 关键词：Renal function ; chronic heart failure ; prognosis ; chronic kidney disease
• 刊名：Journal of Cardiac Failure
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：23
• 期：1
• 页码：2-9
• 全文大小：687 K
• 卷排序：23

文摘

The mean deterioration in estimated GFR in patients with chronic heart failure was 1.5 mL   min−1   1.73 m−2 in the first year, which can be considered to be moderate. A minority of patients (one sixth) experienced a strong decrease in renal function in the 1st year (15 mL   min−1   1.73 m−2). Factors associated with progressive decline were baseline renal dysfunction, COPD, and loop diuretic use. Lower renal function at baseline and any decrease over time was strongly associated with worse clinical outcomes, including cardiovascular death and heart failure hospitalization.